Abstract
ZYM-201 is a methyl ester of a novel triterpenoid glycoside. It is isolated from Sanguisorba officinalis, a widely used medicinal plant in Korea, China, and Japan, that is prescribed for
various diseases such as diarrhea, chronic intestinal infections, duodenal ulcers,
and bleeding. In this study, the antihyperlipidemic effect of the salt form (sodium
succinate) of ZYM-201 was examined using streptozotocin (STZ)-treated hyperglycemic
rats. Oral administration of ZYM-201 sodium succinate (3 to 10 mg/kg) resulted in
recovery of the increased serum levels of triglyceride (TG) and total cholesterol
(TC) back to normal levels. Elevated levels of serum lipoproteins, such as high-density
lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein
(VLDL), were also significantly restored by this compound without altering 3-hydroxy-3-methylglutaryl
(HMG)-CoA reductase activity. Finally, ZYM-201 sodium succinate displayed antioxidative
properties, including suppression of lipid peroxide and hydroxyl radical generation
and upregulation of superoxide dismutase (SOD) activity. Therefore, our data strongly
suggest that ZYM-201 sodium succinate can be used as a remedy for the treatment of
diabetes-derived hyperlipidemic disorders such as atherosclerosis and vascular diseases.
Key words
ZYM-201 sodium succinate -
Sanguisorba officinalis L. - Rosaceae - triterpenoid glycoside - diabetes - antihyperlipidemic activity
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1 These authors contributed equally to this work.
Jae Youl Cho, PhD
Department of Genetic Engineering
Sungkyunkwan University
300 Chuncheon-dong
Suwon 440-746
Korea
Phone: +82 31 2 90 78 68
Fax: +82 31 2 90 78 70
Email: jaecho@skku.edu
Jaehwi Lee, PhD
College of Pharmacy
Chung-Ang University
221 Heukseok-dong
Seoul 156-756
Korea
Phone: +82 2 8 20 56 06
Fax: +82 2 8 16 73 38
Email: jaehwi@cau.ac.kr
